The teacher-searchers

Agri-food and Nutrition Sciences Department

Microbiology

– Antibacterial resistance and the search for new therapeutic solutions to bacterial infections
– Natural bacterial communities and bioactive bacterial metabolites

Identifiers
ORCID: 0000-0003-1977-2812
IDHAL: michael-mourez

PURPAN Deputy General Manager and Director of Education

– Degree in Engineering from the Ecole Polytechnique
– Degree in Engineering from AgroParisTech
– PhD in Fundamental Bacteriology
– Diplôme Universitaire (university degree) – Advanced Biomedical Training

– Director of the Bacteriology & Omics Department, Evotec Infectious Diseases, Lyon, France
– Director of the Bacteriology Department, Infectious Diseases Unit, Sanofi R&D, Toulouse / Lyon, France
– Associate Professor, Faculty of Veterinary Medicine, Université de Montréal, Canada
– Research Fellow, Harvard Medical School, Boston, USA

# Couderc C, Abi Khalil R, Tormo H, Paes C, Mourez M, Daveran-Mingot ML. Impact of the use of an indigenous starter on microbial community structuring and aromatic profile of Rocamadour protected designation of origin cheese. 2024. LWT – Food Science and Technology. 210: 116813. https://doi.org/10.1016/j.lwt.2024.116813.
# Couturier C, Groß S, von Tesmar A, Hoffmann J, Deckarm S, Fievet A, Dubarry N, Taillier T, Pöverlein C, Stump H, Kurz M, Toti L, Haag Richter S, Schummer D, Sizun P, Hoffmann M, Prasad Awal R, Zaburannyi N, Harmrolfs K, Wink J, Lessoud E, Vermat T, Cazals V, Silve S, Bauer A, Mourez M, Fraisse L, Leroi-Geissler C, Rey A, Versluys S, Bacqué E, Müller R, Renard S. 2022. Structure Elucidation, Total Synthesis, Antibacterial In Vivo Efficacy and Biosynthesis Proposal of Myxobacterial Corramycin. Angew Chem Int Ed Engl. 61(51):e202210747 doi: 10.1002/anie.202210747.
# Dumont E, Vergalli J, Conraux L, Taillier C, Vassort A, Pajovic J, Réfrégiers M, Mourez M, Pagès JM. 2019. Antibiotics and efflux: combined spectrofluorimetry and mass spectrometry to evaluate the involvement of concentration and efflux activity in intracellular antibiotic accumulation. J. Antimicrob Chemother. 74(1):58–65. doi: 10.1093/jac/dky396.
# Jeannot F, Taillier T, Despeyroux P, Renard S, Rey A, Mourez M, Poeverlein C, Khichane I, Perrin MA, Versluys S, Stavenger RA, Huang J, Germe T, Maxwell A, Cao S, Huseby DL, Hughes D, Bacqué E. 2018. Imidazopyrazinones (IPYs): Non-Quinolone Bacterial Topoisomerase Inhibitors Showing Partial Cross-Resistance with Quinolones. J Med Chem. 61(8):3565–3581. doi: 10.1021/acs.jmedchem.7b01892.
# Côté J.-P., F. Berthiaume, S. Houle, J.M. Fairbrother, C.M. Dozois, M. Mourez. 2012 Identification and mechanism of evolution of new alleles coding for the AIDA-I autotransporter of porcine pathogenic Escherichia coli. Appl Environ Microbiol. 78(13):4597–605.
# Charbonneau M.-È., J.P. Côté, M.F. Haurat, B. Reiz, S. Crépin, F. Berthiaume, C.M. Dozois, M.F. Feldman, M. Mourez 2012 A structural motif is the recognition site for a new family of bacterial protein O-glycosyltransferases. Mol Microbiol. 83(5):894–907.
# Côté J.-P., M. Mourez 2011 Structure-function analysis of the TibA self-associating autotransporter reveals a modular organization. Infect Immun. 79(5):1826-32.
# Girard V., J.-P. Côté, M.-È. Charbonneau, M. Campos, F. Berthiaume, Hancock M.A., N. Siddiqui, M. Mourez. 2010. Conformation change in a self-recognizing autotransporter modulates bacterial cell-cell interaction. J. Biol. Chem. 285(14): 10616-26.
# Charbonneau, M.-È., V. Girard, A. Nikolakakis, M. Campos, F. Berthiaume, F. Dumas, F. Lépine, M. Mourez. 2007. O-linked glycosylation ensures the normal conformation of the autotransporter adhesin involved in diffuse adherence (AIDA-I). J. Bacteriol. 189(24):8880-9.
# Rutherford, N., M.-E. Charbonneau, F. Berthiaume, J.-M. Betton, M. Mourez. 2006. The periplasmic folding of a cysteineless autotransporter passenger domain interferes with its outer membrane translocation. J. Bacteriol. 188: 4111–4116.
# Mourez, M., M. Yan, D.B. Lacy, L. Dillon, L. Bentsen, A. Marpoe, C. Maurin, E. Hotze, D. Wigelsworth, R.A. Pimental, J.D. Ballard, R.J. Collier, R.K. Tweten. 2003. Mapping dominant-negative mutations of anthrax protective antigen by scanning mutagenesis. Proc. Natl. Acad. Sci. U. S. A. 100:13803-8
# Mourez, M., R. S. Kane, J. Mogridge, S. Metallo, P. Deschatelets, B. R. Sellman, G. Whitesides, R. J. Collier. 2001. Designing a Polyvalent Inhibitor of Anthrax Toxin. Nat. Biotechnol. 19: 958–961.
# Sellman, B. R., M. Mourez, R. J. Collier. 2001. Dominant Negative Mutants of Protective Antigen: An Approach to Therapy of Anthrax. Science 292: 695–697.
# Mourez, M., M. Hofnung, E. Dassa. 1997. Subunit interactions in ABC transporters. A conserved sequence in hydrophobic membrane proteins of periplasmic permeases defines an important site of interaction with the ATPase subunits. EMBO J. 16: 3066–3077.

Internal Research Unit UPR Occi’Food (Oxidation, Conservation, Characterization, Innovation, Food Fermentation)