The teacher-searchers

Animal Sciences and Livestock Systems Department

• Living Lab. Dairy cows & Poultry
• Biodiversity observatory

• Animal physiology
• Animal health
• Safety of foodstuffs of animal origin
• Applied botany

• Pasture biodiversity and animal health
• Phytotherapy, profitable use of secondary metabolites and animal health
• Integrated management of animal and plant health
• Plant toxicity and animal health
• Pasture biodiversity and bioindicators
• Small ruminant sectors and adaptation to climate change
• Organic farming

Head of the Animal Sciences and Livestock Systems Department

• Inter-University Diploma in Phytotherapy, Faculty of Pharmacy, Nantes (44), 2011
• Doctorate in Pathology, Toxicology, Genetics & Nutrition, from the University of Toulouse (31), 2008
• Master 2 Research: Quality and Food Safety, INP/ENSAT (31), 2005
• Doctor of Veterinary Medicine Degree (“Diplôme d’Etat”). ENVT (Toulouse National Veterinary School) (31), 2005

2013–2020: Lecturer in Food Chain Safety & Animal Health UMR MoSAR (System Modelling Applied to Ruminants) INRAE (National Agricultural, Food and Environment Research Institute)/AgroParisTech

2012-1013: ENVT (Toulouse National Veterinary School) postdoctoral researcher. Innov’herba project, Study of the ingestion of endophyte-infected grasses by dairy ewes. Metabolic (by metabonomics) and toxicological aspects

2011–2012: ATER (Temporary teaching and research assistant) at Joint Research Unit UMR INRAE (National Agricultural, Food and Environment Research Institute) AGIR (Agroecology, Innovations and Ruralities), ORPHEE team. Study of variations in Fabaceae tannin content as a function of environmental stress factors, its use in animal health in natural areas, and its impact on the management of floristic and forage diversity

2010–2011: ENS Lyon postdoctoral researcher. ANR mQTL project. Study of the links between metabolism and genetics in the pathophysiology of the metabolic syndrome

2005–2009. PhD from the University of Toulouse in “Pathology, Toxicology, Genetics and Nutrition” INP-ENSAT. Joint Research Unit UMR 1089 INRA (National Agricultural Research Institute)/ENVT (Toulouse National Veterinary School)
Teaching (Monitoring): Recognition of forage and cereal plants, floristic inventories, diagnosis and toxicology data, Agronomy/Environment teaching unit, INP-ENSAT (31)
Research: Study of metabolic disturbances induced in a mouse model by the ingestion of Hypochoeris radicata (L.), a plant toxic to the equine species. Validation of the metabonomic approach through behavioral studies and brain imaging

Since 2013:
Veterinarian advisor for Animal welfare structures
Animal experimentation ethics committee veterinarian

• Tiphaine Blanchard, Marco Fantinati, Céline Domange, Nathalie Priymenko. Two cases of non-fatal poisoning of horses with Goat’s rue (Galega officinalis L). Journal of Equine Veterinary Science. Volume 117, October 2022

• S. Giger-Reverdin, C. Domange, L. Broudiscou, D. Sauvant, V. Berthelot. Rumen function in goats, an example of adaptive capacity. Res. J. Dairy Sci. 2020, 87 45–51

• T. Abu-Izneid, A. Rauf, S. Uzair Ali Shah, A. Wadood, M. I. S. Abdelhady, N. Priymenko, C. Domange, N. Mansour, S. Patel. In vivo study on analgesic, muscle-relaxant, sedative activity of extracts of Hypochaeris radicata and in silico evaluation of hypochoeris glucoside and guaiane-type sequiterpene. BioMed Research International. 2018, 10 p.

• C. Domange & V. Berthelot. Chapter 3. Qualité sanitaire de la viande de petits ruminants. 3.1. Risques biologiques. 3.1.1. Bactériologie des denrées carnées issues de petits ruminants. Alimentation des animaux et qualité de leurs produits. Coordinator: V. Berthelot. Edition Lavoisier Tec&Doc. 29/01/2018

• M.E. Dumas, C. Domange, S. Calderari, A. Rodríguez Martínez, R. Ayala, S.P. Wilder, N. Suarez Zamorano, S.C. Collins, R.H. Wallis, Q. Gu1, Y. Wang, C. Hue, G.W. Otto, K. Argoud, V. Navratil, S.C. Mitchell, J.C. Lindon, E. Holmes, J.B. Cazier, J.K. Nicholson, D. Gauguier. Topological analysis of metabolic networks integrating co-segregating transcriptomes and metabolomes in type 2 diabetic rat congenic series. Genome Med. 2016, 8–101.

• N. Zbib, C. Repussard, D. Tardieu, N. Priymenko, C. Domange, P. Guerre. Toxicity of endophyte-infected ryegrass hay containing high ergovaline level in lactating. J. Anim. Sci. 2015, 93, 4098–4109

• N. Zbib, C. Repussard, D. Tardieu, N. Priymenko, C. Domange, P. Guerre. Ergovaline in Tall Fescue and Its Effect on Health, Milk Quality, Biochemical Parameters, Oxidative Status, and Drug Metabolizing Enzymes of Lactating Ewes. J. Anim. Sci. 2014, 92, 5112–5123

• C. Domange, H. Schroeder, N. Violle, J. Peiffer, C. Canlet, A. Paris and N. Priymenko. Mining the brain metabolome to understand behavioural disruptions induced in mice fed Hypochoeris radicata (L.), a neurotoxic plant for horses. NeuroToxicology 2013, 38, 74–83.

• N. Villa-Vialaneix, N. Hernandez, A. Paris, C. Domange, N. Priymenko, P. Besse. On combining wavelets expansion and sparse linear models for regression on metabolomic data and biomarker selection. Communication in Statistics – Simulation and Computation. 2013

• L. Shintu, R. Baudoin, V. Navratil, C. Pontoizeau, M. Defernez, B.J. Blaise, C. Domange, A. Péry, P. Toulhoat, C. Legallais, C. Brochot, E. Leclerc, and M.E. Dumas. Metabolics-on-chip and predictive systems toxicology in microfluidic bioartificial organs. Anal. Chem. 2012, 84, 1840-8.

• C. Pontoizeau, J.F. Fearnside, V. Navratil, C. Domange, J.B. Cazier, C. Fernández-Santamaría, P.J. Kaisaki, L. Emsley, P. Toulhoat, M.T. Bihoreau, J.K. Nicholson, D. Gauguier, M.E. Dumas. Broad-ranging natural metabotype variation drives physiological plasticity in healthy control inbred rat strains. J Proteome Res. 2011, 10(4):1675-89

• B.J. Blaise, V. Navratil, C. Domange, L. Shintu, M.E. Dumas, B. Elena-Herrmann, L. Emsley, P. Toulhoat. Two-dimensional statistical recoupling for the identification of perturbed metabolic networks from NMR spectroscopy. J Proteome Res 2010, 9(9): 4513-20.

• C. Domange, A. Casteignau, G. Collignon, M. Pumarola, N. Priymenko. Longitudinal study of Australian stringhalt cases in France. J Anim Physiol Anim Nutr (Berl) 2010, 94(6), 712-20.

• C. Domange, C. Canlet, A. Traore, G. Biélicki, C. Keller, A. Paris, N. Priymenko. Orthologous metabonomic qualification of a rodent model combined with magnetic resonance imaging for an integrated evaluation of the toxicity of Hypochœris radicata. Chem. Res. Toxicol. 2008, 21 (11), 2082–2096; Editorial of the journal Chem. Res. Toxicol. 2008.

UMR MoSAR (System Modelling Applied to Ruminants)